Sildenafil Patient Tips

European Journal of Obstetrics & Gynecology and Reproductive Biology
25 Answers Page 2
Similar questions
1. How it works
How does Viagra work?
Are there other uses for this medicine?

(1999) Safety and efficacy of sildenafil in postmenopausal women with female sexual dysfunction. Learn more about compounded Sildenafil creams made for women.

Sildenafil's effect duration in women may range from 4 to 6 hours.
It may help women experiencing low libido linked to blood flow issues.
The drug’s efficacy in women is less predictable than in men.
Female sexual dysfunction has multiple causes beyond blood flow.

Sildenafil and its brand medication, Viagra, has been around since 1998 for the treatment of erectile dysfunction in men.

European Journal of Obstetrics & Gynecology and Reproductive Biology

(2011) Sexual dysfunction and difficulties in Denemark: Prevelance and associated socio-demographic factors. Arch sex behave 40(1): 121-132. Abdallah I Y, AbdelrahmanSh (2014) female sexual dysfunction in relation to the age of marriage .thesis submitted for fulfillment of master degree in dermatology and Andrology in Banha city, Banha University, Egypt. Omidi A, Ahmedvand A, Najarzadan MR, Mehrzad F (2016) Compairing the effect of treatment with sildenafil and cognitive-behavioral therapy on treatment of sexual dysfunctioninwomen: arandomized controlled clinical trials. Chivers MI, Rosen RC (2010) Phosphodiesterase type 5 and female sexual response.

Patient resources

J Sex Med 7(2): 858-872. Leddy LS, Yang CC, Stuckey BG, Sudworth M, Haughie S, et al. (2012) Influence of sildenafil on genital engorgement in women with female sexual arousal disorder. Sildenafil increases serum testosterone levels by a direct action on the testes. Lo Monte G, Graziano A, Piva I, Marci R (2014) Women taking the blue pill (sildenafil citrate) such big deal. And, since then, it has revolutionized how doctors approach male sexual health complaints.

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Viagra Generic	200mg	90 + 6 Pills	170.79€ 162.66€
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Viagra Generic	25mg	270 + 8 Pills	184.26€ 175.49€
Viagra Generic	150mg	60 + 4 Pills	111.25€ 105.95€
Kamagra	100mg	360 + 6 Pills	839.95€ 799.95€
Kamagra	100mg	60 + 4 Pills	201.34€ 191.75€
Viagra Generic	50mg	120 + 6 Pills	129.64€ 123.47€
Kamagra Polo	100mg	272 + 12 Pills	622.94€ 593.28€
Viagra Generic	200mg	60 + 4 Pills	125.19€ 119.23€
Kamagra Oral Jelly	100mg	220 + 18 Sachets	662.24€ 630.70€
Kamagra Oral Jelly	100mg	30 + 5 Sachets	136.20€ 129.71€

This has lead to the question of if Sildenafil or Viagra may just have positive sexual effects in women as well.

25 Answers Page 2

Proposed reasons for the unconvincing efficacy of sildenafil in women have included failure to adequately characterize the study populations, differences in the physiologic response to sildenafil in men and women, and the mechanism of action of the drug needing to be central and not peripheral. It is also possible that lack of concordance between physiological and subjective aspects of women’s sexual experiences need to be further investigated [16]. This study revealed no significant association between both groups in comparison of post treatment regarding sexual dysfunction assessment except in orgasm less than half times, which become (84.6%) versus (30.8%) in sildenafil group and placebo group respectively. These results can be supported by the study of Leddy et al. [17]; 13 of 19 (68%) subjects achieved a ≥50% increase in clitoral engorgement from baseline when administered sildenafil or placebo 30 minutes after dose administration.

Research on Sildenafil Citrate for Women

At 60 minutes after administration, 17/19 (89%) subjects receiving sildenafil and 16/19 (84%) subjects receiving placebo had responded (P value 0.3). [16] used self-reported measures of sexual function which showed mixed results whereas studies examining physiological effects of PDE5i on genital vasocongestion consistently report significant effects on genital sexual response. The improvnent in FSFI in-group A may be related to increase in androgen level as there might be a positive correlation between sildenafil intake and increase testosterone blood level [18]. Also it increases the pelvic blood flow which may give more improvement in lubrication and decrease pain during sexual act and increase overall sexual satisfaction. [19] stated that sildenafil citrate only acts on the physical phenomena of arousal and does not completely respond to the complexity of female sexual arousal disorders (FSADs). Men and Women do have different sexual anatomies, but at the core of arousal is the same function involving smooth muscle relation and increased blood flow to the genital area, which is the underlying function of PDE-5 inhibitors such as Sildenafil.

1. How it works

On the same side, the study carried by Omidi et al. [13] in Iran compared the two groups in terms of primary mean scores of sexual function, sexual satisfaction, and marital satisfaction showed similarities in terms of factors and prevalence of disorders at the beginning of the study. In the treatment arm of the present study, there was improvement in sexual dysfunction particularly in sexual desire, maintenance of lubrication, orgasm and satisfaction. Regarding the desire, the obvious change was in patients with no desire weekly pretreatment to improve from zero to 61.5% post-treatment. The orgasm differences in women who achieved orgasm less than half the time were 38.5% versus 84.6% pre- and post-treatment respectively (Table 2).

Premenopausal women affected by sexual arousal disorder treated with sildenafil: a double-blind, cross-over, placebo-controlled study

Indeed these results were opposite to the study of Dasgupta et al. [14] which included 19 women completed the 2 arms of the double-blind phase and 12 completed the optional open label extension phase. Statistically significant improvement following sildenafil was only reported in the lubrication domain of sexual function during the double-blind phase. There was no overall change in quality of life after sildenafil. [15] found that efficacy was shown on only one sexual function measure and only in a sildenafil oral jelly 100mg lovegra small subsample of women who sildenafil 45 mg chewable tablets had no associated hypoactive sexual desire disorder (HSDD) and had sufficient estradiol and free testosterone concentration or were receiving estrogen and/ or androgen replacement therapy. One placebo-controlled trial in women who were experiencing sexual dysfunction while taking an antidepressant found that adding in Sildenafil helped improve

How does Viagra work?

These results mean that sexual function of women resident in cities is better than those living in villages. This may be due to better level of education, sexual knowledge or socioeconomic factors. [11] concluded that men and women who had trouble in paying their bills were twice as likely to report sexual dysfunctions compared with peers without such economic troubles. In women, there was also a statistically significant trend of increasing sexual dysfunction prevalence with decreasing income. As regard masturbation practice before marriage, it was more common among participants living in cities.

Physiology of female sexual function: Animal models

In the current study 53.85% of participants living in towns and 46.15% in villages; about 80.76% of them stated that they did not know what masturbation is. This can be attributed to customs and traditions which to some extent discourage sexual education especially among females. [12] found that sexual satisfaction seemed to be associated with residence as (26.4%) and (39.1%) of participants living in town were very and moderately sexually satisfied compared to (18.2%) and (20.5%) of women living in villages who were very and moderately sexually satisfied. Regarding masturbation (17.3%) of town residents practiced it before marriage versus (11.4%) of those living in a village and (59%) of participants living in town and (54.5%) of participants living in rural areas stated that they did not know what masturbation is. This study revealed no significant differences between both groups regarding their baseline sexual desire or orgasm (Table 2). reported arousal, lubrication, and orgasm as compared to the placebo groups, but did not change any reported pain from sexual intercourse.

Parameter	Typical Value	Notes
Absorption	Rapid, peaks in 30-120 minutes	Food can delay absorption
Distribution	Widely distributed in tissues	Binds to plasma proteins
Metabolism	Liver CYP3A4 enzymes	Excreted mainly in feces
Half-life	4-5 hours	Duration of action varies

Another placebo-controlled study looked into using Sildenafil in postmenopausal women with FSAD and found significant improvements in reported arousal, as long as they did

Are there other uses for this medicine?

In fact, encouraging results were achieved in specific groups of patients affected by secondary FSADs (e.g., diabetes mellitus, multiple sclerosis, chronic antidepressant users) in which the genital arousal disorder is clearly connected with a neurological or vascular injury. [20] reported only lubrication changes in vaginal and clitoral sensitivity in patients treated with sildenafil. When examining the effects of sildenafil on female sexual dysfunction, it was found that sildenafil may increase congestion of the vagina, but it has no effect on excitement. This difference in results can be attributed to the manner and extent of drug administration, assessment of sexual status, and cultural status of the subjects in the study. Moreover, in most studies, the sample size has been very small, which makes their validity questionable.

Female sexual response: the role of drugs in the management of sexual dysfunction

The limitation of this study is that it was conducted on only Egyptian patients, so further well-designed studies are needed to see if the same conclusions apply to other races. On the other hand, points of strength include among others, the good sample size and the prospective randomized double-blinded study design. Sildenafil citrate seems to improve orgasm in a sample of Egyptian females with sexual dysfunction. Desilva P (1995) Sexual dysfunction in S.J.E Lindsay and G.E.Powell, The hand book of lineal and adult psychology. London and New York rout ledge (2): 199-288. not also have hypoactive sexual desire disorder (HSDD).One study considers PDE-5 inhibitors, such as Sildenafil, to have conflicting results when it comes to treating FSAD.

Country	Status	Notes
USA	Off-label, experimental use	Not FDA approved for women
UK	Similar to US, off-label	Prescription only
Australia	Not approved for women	Research under consideration
Canada	Experimental use in clinical trials	Not commercially available

Suggesting that these medications should be kept as the last option due to FSAD being composed of many different factors including medical, psychological, and sexual, and requiring a global approach to treatment.

Region	Cost Range per Dose	Availability	Notes
North America	$10-$25	Prescription only	Off-label use limited
Europe	€8-€20	Prescription, some OTC in countries	Varies widely
Asia	$5-$15	Often available OTC or via clinics	Cost-effective options
Australia	$15-$30	Prescription only	Under medical supervision